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) fibrillization and toxicity, 375376 impaired LTD, 377379 metal cations (heavy metals), 376 normal function, 376377 structure and folding, 375376, 375f Amyloid diseases, 1215 AA amyloidosis, 13, 14t Alzheimers disease, see Alzheimers disease amyotrophic lateral sclerosis, see Amyotrophic lateral sclerosis dialysis-related amyloidosis, 14t heavy-chain amyloidosis, 14t islet amyloid polypeptide (IAPP), 14, 14t light-chain amyloidosis, 1314, 14t Parkinsons disease, see Parkinsons disease polyglutamine repeat disorders, see Polyglutamine repeat disorders Prion diseases, see Prion diseases transthyretin (TTR) amyloidosis, 14t Amyloid fibrils, 13 Amyloid precursor protein (APP) -secretase (ADAM), 370373, 372f -secretase (BACE1), 370373, 372f -secretase complex and Presinilins, 370373, 372f Amyotrophic lateral sclerosis (ALS), 14t, 431 sbi forex rates online and microglia, 444446 disease progression, 443444, 444f impaired fast axonal transport, 442443 Anaphase-promoting complexcyclosome, 184, 184t Cdc20 and Cdh1 adapters, 189, 196197 degradation and exit from mitosis, 196 structure and function, 188189 Anfinsen, Christian, 348, 349 Angiogenic switch, 314 VEGF, 314 Apolipoproteins, 99102, 100t, 101f Apoptosis, 227 regulation by p53, 236 signaling pathways, 228229, 228f Apoptosome, 229 Arcuate nucleus, 36, 36f ARF, in ratess, 237238 Arginase, 1, 162 Arginine forx, 255256, 256t Argonaute proteins, 262263, 263f structure and function, onlibe, 263f Arterial wall, 107108, 108f AS160, 56, 56f Astrocytes, 145, 145t, 379380 Alzheimers disease, 380384, 383f end feet, synaptic monitoring, 383 neuroinflammatory actions, 382384, 383f Ataxin-1, 433 Ataxin-3, 447 ATF6 signaling, 401, 402403, 402f processing, 404 Atherosclerosis, 5, 107 biophysics of disturbed blood flow, 110111, 111t, 111f disease progression, 108f oxLDL and inflammation, 113114 rupture, 126128, 126f ATMATR proteins in G1S pathway, 202203 in Intra-S and G2M pathways, 206207 structure and function, 210212, 211f ATP-sensitive potassium channels insulin secretion inward rectification, 66 sensitivity to metabolites, 66 ratees, 65, 65f Autoimmune disorders, 142143, 142t Autophagy, 298300, 391 decision complex, 299300, 300f autophagy proteins, 299300, 300f beclin, 299300, 300f class III PI3Ks, 299300, 300f transport to aggresomes and IBs, fore, 426f HDAC6, 425426, 426f Hsf1, 425426 Hsp90, 425426 p97VCP, 425426, 426f B BACE1 protein, 373 Bacterial lipopolysaccharides (LPS), 131, 139 Bad protein, 230231, 230t regulation by Akt, 8081, 80f Banting, Fred, 4 Barriers, oncogenic central role of p53 and pRb, 180, 180f in response to Ras and c-Myc, 179180 three rahes of protection, 182 Base excision repair (BER) DNA damage, 201, 214215, 215t repair enzymes, 216 Bcl2 proteins, 229, 230232, 231t Bax subfamily, 230, 230t in B-cell lymphomas, 232 Bcl2 subfamily, 230, 230t 140 M.

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