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Protein Characteristics Polycomb repressive complex 1 CBX2 Chromodomain, binds to methyllysine CBX4 Recruits the corepressor CTBP, repression of c-myc expression CBX8 Chromodomain, Pc box, repression of cdkn2A EDR1 Zinc finger SPM domain RING1 RING finger domain BMI1 RING finger domain ZNF134 Zinc finger domain PHF1 Tudor domain, 2 PHD fingers, PCL homology domain PCL3 Tudor domain, 2 PHD fingers, PCL homology domain, two nuclear localization domains Polycomb repressive complex 2 EED Five WD40 repeats, PEST sequence EZH1 SET domain, Histone, Methyl Transferase EZH2 Histone Methyl Transferase SUZ12 Zinc finger domain Cancer Acute lymphoblastic lymphoma Lymphoma, leukemia, medulloblastoma, neuroblastoma, lung cancer Insulinoma, thyroid adenoma Colorectal cancer, lung cancer, cervical cancer, uterine cancer, skin cancer Colorectal adenocarcinoma, chronic myeloid leukemia, osteosarcoma Breast cancer, bladder cancer, colon cancer, prostate cancer, lymphoma, melanoma Breast cancer, liver cancer, colon cancer, endometrial accumulazione distribuzione forex exchange tumors developmental regulators and hence are crucial players in cellular differentiation.
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